The common Castelmayran occupies mainly the lower and middle terraces of the Garonne.
The population was present in Paleolithic and the Gallo-Roman period.
Castelmayran is a manor from 1166, the priory was surrendered to the abbey of Moissac in 1249. The current building shows two medieval stone buttresses on which was directly attached to facade and bell tower of the 17th century.